懂色帝

孟祥周

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:[email protected]
  • 长聘教轨副教授,博士生导师,主要研究真核生物DNA复制、DNA损伤修复与基因组稳定性维持的分子机制。

学术经历

  • 2020.12-至今,懂色帝 ,长聘教轨副教授,博导
  • 2016-2020 美国纪念斯隆凯特琳癌症中心,博士后
  • 2009-2015 美国德克萨斯农工大学,生物化学,博士
  • 2006 -2009 山东大学,微生物学,硕士
  • 2002-2006 山东大学,生物基地班,学士

研究方向

DNA损伤修复与基因组稳定性

DNA损伤修复与基因组稳定性

真核生物DNA复制的分子机制

真核生物DNA复制的分子机制

代表论著

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    Sohail Ahmad#, Siying Zhang#, Xiangzhou Meng* (2025) A conserved thumb domain insertion in DNA polymerase epsilon supports processive DNA synthesis. Nucleic Acids Res. 2025 53(5):gkaf190. doi: 10.1093/nar/gkaf190.

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    Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023) Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes & Development. doi:10.1101/gad.350054.122

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    Meng X, Dang HQ, Kapler GM. (2023) Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena. Microorganisms. 11 (2), 491.

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    Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X*. (2020) DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11(1):2437.

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    Meng X#, Wei L#, Peng XP, and Zhao X*. (2019) Sumoylation of DNA polymerase ε by the Smc5/6 complex contributes to DNA Replication. PLoS Genet. 15(11):e1008426.

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    Meng X, Zhao X*. (2017) Replication fork regression and its regulation. FEMS Yeast Res. 17(1):fow110.

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    Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021) The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A.118(8):e2020185118.

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    Wan B, Wu J, Meng X, Lei M, Zhao X*. (2019) Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75(2):238-251.

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    Lee PH#, Meng X#, Kapler GM*. (2015) Developmental regulation of the Tetrahymena thermophila origin recognition complex. PLoS Genet. 11(1):e1004875.